Conformation of the acto-myosin complex in the presence of N-benzyl-p-toluene sulphonamide (BTS)
نویسنده
چکیده
BTS is an allosteric, small molecule inhibitor of the ATPase activity of myosin II (1). It has been shown that BTS is remarkably specific for the fast skeletal myosin isoform. In solution studies it was found that BTS decreases the rate of phosphate release from myosin and weakens the apparent affinity of S1.ADP for actin (2). These effects seem to be responsible for the reduced force production in demembranated fast skeletal muscle fibers of rabbit and frog. The structural conformation of the acto-myosin complex with BTS, however, is unclear.
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تاریخ انتشار 2010